Grace Flanagan Martindale: Protagonist, widow of the late Right Reverend Martindale; Protectress of her two sisters, Hope and Mercy.
Alexander Armistead: A French-American fur trapper who lives amongst the Native Americans and he has strong feelings for Grace.
Gabriel Larquette: The good friend of Alexander who was once married to two Native American women.
Hope Flanagan: The middle Flanagan sister who has a zest for life.
Mercy Flanagan: The youngest Flanagan sister.
Dr. Marcus Whitman: The arrogant doctor who runs the Whitman Mission alongside his wife, Narcissa. The Cayuse are not too enthused with him.
Telokite: A Cayuse Native American who views the Caucasian settlers as enemies. He believes that Dr. Whitman is purposely harming his people.
Mrs. Narcissa Whitman: The wife of Dr. Whitman who runs the Whitman Mission alongside him.